Edward Osborne was born to Thomas Osborne V (1690-1755) and Ann Durfee Worsham Osborne 1696-1744) in 1708 at Henrico. There were several Osbornes with the given name of Edward during the Virginia colonization from 1610 through the mid 1700s. This Edward Osborne was the brother of Thomas VI (1715-1787) and Reps (1723-1808).
Around 1735 Edward married Frances Hancock (1710-1793). Frances was the daughter of Samuel and Johanna Hancock of Chesterfield County, VA. They would have lived in close proximity to Coxendale.
Edward and Frances had three sons:
George Osborn (1739-1783)
Edward died in 1770 in Laurens County, SC.